Transmembrane Transporters
in Health and Disease

Publikationen

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2012

2011

Rabl U, Pezawas L, Meyer-Lindenberg A,

Emotion and Genetics

In: Ochsner K, Kosslyn S, editors. Oxford Handbook of Cognitive Neuroscience. Oxford, UK: Oxford University Press. in press. (2011)

Scharinger C, Rabl U, Pezawas L, Kasper S,

The genetic blueprint of Major Depressive Disorder: contributions of imaging genetics studies

The World Journal of Biological Psychiatry, Oct;12(7):474-88. Epub 2011 Aug 11. (2011)

Scharinger C, Bartova L, Pezawas L,

Brain-derived neurotrophic factor: a peripheral biomarker for major depressive disorder and antidepressant efficacy?

Personalized Medicine;8:115-117. (2011)

Kuchler K

The ABC of ABCs: multidrug resistance and genetic diseases

FEBS J. 2011 Sep;278(18):3189. doi: 10.1111/j.1742-4658.2011.08234.x. Epub 2011 Aug 1.

Klein C, Kuchler K, & Valachovic M

ABC proteins in yeast & fungal pathogens

Essays in Biochemistry - ABC Transporters (Guest Ed. Frances Sharom). Portland Press, London, (2011)

Tscherner M., Schwarzmüller T., & Kuchler K.

Pathogenesis and antifungal drug resistance of the human fungal pathogen Candida glabrata

Pharmaceuticals 4: 169-186; doi:10.3390/ph4010169 (2011)

Rabl U, Scharinger C, Hofmaier T, Freissmuth M, Pezawas L.

Genetic regulation of emotion brain circuitries

In: López-Muñoz F, Álamo C, editors. Neurobiology of Depression. Boca Raton, USA: CRC Press.;75-95. (2011)

Steinkellner T, Freissmuth M, Sitte HH, Montgomery T

The ugly side of amphetamines: short- and long-term toxicity of 3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy'), methamphetamine and D-amphetamine

Biol Chem.;392:103-15. (2011)

Weissensteiner R, Steinkellner T, Jurik A, Bulling S, Sandtner W, Kudlacek O, Freissmuth M, Ecker GF and Sitte HH*

Towards an understanding of the psychostimulant action of amphetamine and cocaine. In: SENSORY PERCEPTION, Mind and Matter

Eds.: Barth F.G., Giamperi-Deutsch P., Klein H.-D. (2011)

Wildling L, Rankl C, Haselgruebler T, Gruber HJ, Holy M, Newman AH, Zou MF, Zhu R, Freissmuth M, Sitte HH, Hinterdorfer P

Probing the binding pocket of the serotonin transporter by single molecular force spectroscopy on living cells

J Biol Chem. 2012 Jan 2;287(1):105-13. Epub 2011 Oct 27.

Brast S, Grabner A, Sucic S, Sitte HH, Hermann E, Pavenstädt H, Schlatter E, and Ciarimboli G

The cysteines of the extracellular loop are crucial for trafficking of human organic cation transporter 2 to the plasma membrane and are involved in oligomerization

FASEB J 2011 Nov 15. [Epub ahead of print]

Bauer M, Zeitlinger M, Karch R, Matzneller P, Stanek J, Jäger W, Böhmdorfer M, Wadsak W, Mitterhauser M, Bankstahl JP, Löscher W, Koepp M, Müller M, Langer O

P-glycoprotein mediated interaction between (R)-[11C]verapamil and tariquidar at the human blood-brain barrier studied with positron emission tomography, a comparison with rat data

Clin Pharmacol Ther 2012 Feb;91(2):227-33. doi: 10.1038/clpt.2011.217. Epub 2011 Dec 14.

Navaroli DM, Stevens ZH, Uzelac Z, Gabriel L, King MJ, Lifshitz LM, Sitte HH, Melikian HE

The Plasma Membrane-Associated GTPase Rin Interacts with the Dopamine Transporter and Is Required for Protein Kinase C-Regulated Dopamine Transporter Trafficking

Neurosci. 31(39):13758-70. (2011)

Keller T, Egenberger B, Gorboulev V, Bernhard F, Uzelac Z, Gorbunov D, Wirth C, Koppatz S, Dötsch V, Hunte C, Sitte HH, Koepsell H

The large extracellular loop of organic cation transporter 1 influences substrate affinity and is pivotal for oligomerization

J Biol Chem. 2011 Oct 28;286(43):37874-86.

Wanek T, Kuntner C, Bankstahl JP, Bankstahl M, Stanek J, Sauberer M, Mairinger S, Strommer S, Wacheck V, Löscher W, Erker T, Müller M, Langer O

A comparative small-animal PET evaluation of [(11)C]tariquidar, [ (11)C]elacridar and (R)-[(11)C]verapamil for detection of P-glycoprotein-expressing murine breast cancer

Eur J Nucl Med Mol Imaging. (2011), 39(1):149-59. Epub 2011 Oct 8.

Wagner CC, Simpson M, Zeitlinger M, Bauer M, Karch R, Abrahim A, Feurstein T, Schütz M, Kletter K, Müller M, Lappin G, Langer O

A combined accelerator mass spectrometry-positron emission tomography human microdose study with 14C- and 11C-labelled verapamil

Clin Pharmacokin.; 50(2):111-20. (2011)

Bankstahl JP, Bankstahl M, Kuntner C, Stanek J, Wanek T, Meier M, Ding X-Q, Müller M, Langer O, Löscher W

A novel positron emission tomography imaging protocol identifies seizure-induced regional overactivity of P-glycoprotein at the blood-brain barrier

J Neurosci.; 31(24):8803-11.(2011)

Sucic S, El-Kasaby A, Kudlacek O, Sarker S, Sitte HH, Marin P, Freissmuth M

The serotonin transporter is an exclusive client of the coat protein complex II (COPII) component SEC24C

J Biol Chem; 286:16482-16490, (2011)

Dörner B, Kuntner C, Bankstahl JP, Wanek T, Bankstahl M, Stanek J, Müllauer J, Bauer F, Mairinger S, Löscher W, Miller DW, Chiba P, Müller M, Erker T, Langer O

Radiosynthesis and in vivo evaluation of 1-[(18)F]fluoroelacridar as a positron emission tomography tracer for P-glycoprotein and breast cancer resistance protein

Bioorg Med Chem.; 19:2190-8. (2011)

Borecká, S., E. Pinjon, D. J. Sullivan, K. Kuchler, Jaroslav Blaško & H. Bujdáková

Cdr2 contributes to fluconazole resistance in C. dubliniensis isolates

Can. J. Microbiol. 57:416-426 (2011)

Wildling L, Unterauer B, Zhu R, Rupprecht A, Haselgrübler T, Rankl C, Ebner A, Vater D, Pollheimer P, Pohl EE, Hinterdorfer P, Gruber HJ

Linking of Sensor Molecules with Amino Groups to Amino-Functionalized AFM Tips

Bioconjug Chem.; 22:1239-1248. (2011)

Klepsch F, Chiba P, Ecker GF

Exhaustive sampling of docking poses reveals binding hypotheses for propafenone type inhibitors of P-glycoprotein

PLoS Comp Biol; 7(5):e1002036. Epub 2011 May 12.(2011)

Malle E, Zhou H, Neuhold J, Spitzenberger B, Klepsch F, Pollak T, Bergner O, Ecker GF, and Stolt-Bergner PC

Random mutagenesis of the prokaryotic peptide transporter YDGR identifies potential periplasmic gating residues

J Biol Chem.; 286:23121-31, (2011)

Jabeen I, Wetwitayaklung P, Klepsch F, Parveen Z, Chiba P, Ecker GF

Probing the stereoselectivity of P-glycoprotein – synthesis, biological activity and preliminary docking studies of a set of enantiopure benzopyrano[3,4b][1,4]oxazines

Chem Comm; 47(9) Epub 2010 Dec 21., 2586-2588 (2011)

Parveen Z, Stockner T, Bentele C, Pferschy S, Kraupp M, Freissmuth M, Ecker GF, Chiba P.

Molecular dissection of dual pseudosymmetric solute translocation pathways in human P-glycoprotein

Mol Pharmacol; 79(3):443-452, (2011)

Boubela R.N., Huf W.,Kalcher K., Sladky R., Filzmoser P., Pezawas L., Kasper S., Windischberger C., Moser E.

A Highly Parallelized Framework for Computationally Intensive MR Data Analysis

MAGMA manuscript R. N. Boubela, W. Huf et al

2010

Kohut P, Wüstner D, Hronska L, Kuchler K, Hapala I, Valachovic M.

The role of ABC proteins Aus1p and Pdr11p in the uptake of external sterols in yeast: Dehydroergosterol fluorescence study.

Biochem Biophys Res Commun. 2010 Nov 24. [Epub ahead of print]

Frohner IE, Gregori C, Anrather D, Roitinger E, Schüller C, Ammerer G, Kuchler K.

Weak organic Acid stress triggers hyperphosphorylation of the yeast zinc-finger transcription factor war1 and dampens stress adaptation.

OMICS. 2010 Oct;14(5):575-86. Epub 2010 Aug 20.

Scharinger C, Rabl U, Sitte HH, Pezawas L.

IImaging genetics of mood disorders.

Neuroimage 2010 Nov 15;53(3):810-21. Epub 2010 Feb 13.

Bartova L, Berger A, Pezawas L.

Is there a personalized medicine for mood disorders?

Eur Arch Psychiatry Clin Neurosci. 2010 Nov;260 Suppl 2:S121-6. Epub 2010 Oct 19.

El-Kasaby A, Just H, Malle E, Stolt-Bergner PC, Sitte HH, Freissmuth M, Kudlacek O.

Mutations in the carboxyl terminal SEC24 binding motif of the serotonin transporter impair folding of the transporter.

J Biol Chem. 2010 Dec 10;285(50):39201-10. Epub 2010 Oct 2.

Wagner CC, Langer O.

Approaches using molecular imaging technology - use of PET in clinical microdose studies.

Adv Drug Deliv Rev. 2010 Sep 29. [Epub ahead of print]

Sarker S, Weissensteiner R, Steiner I, Sitte HH, Ecker GF, Freissmuth M, Sucic S.

The high-affinity binding site for tricyclic antidepressants resides in the outer vestibule of the Serotonin transporter.

Mol Pharmacol. 2010 Dec;78(6):1026-35. Epub 2010 Sep 9.

Bauer F, Kuntner C, Bankstahl JP, Wanek T, Bankstahl M, Stanek J, Mairinger S, Dörner B, Löscher W, Mueller M, Erker T, Langer O.

Synthesis and in vivo evaluation of [11C]tariquidar, a positron emission tomography radiotracer based on a third-generation P-glycoprotein inhibitor.

Bioorg Med Chem. 2010 Aug 1;18(15):5489-97. Epub 2010 Jun 22

Mairinger S, Langer O, Kuntner C, Wanek T, Bankstahl JP, Bankstahl M, Stanek J, Doerner B, Bauer F, Baumgartner C, Löscher W, Erker T, Müller M.

Synthesis and in vivo evaluation of the putative breast cancer resistance protein inhibitor [11C]methyl 4-((4-(2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl)phenyl)amino-carbonyl)-2-(quinoline-2-carbonylamino)benzoate.

Nucl Med Biol. 2010 Jul;37(5):637-44. Epub 2010 Apr 8

Kuntner C, Bankstahl JP, Bankstahl M, Stanek J, Wanek T, Stundner G, Karch R, Brauner R, Meier M, Ding X, Müller M, Löscher W, Langer O.

Dose-response assessment of tariquidar and elacridar and regional quantification of P-glycoprotein inhibition at the rat blood-brain barrier using (R)-[(11)C]verapamil PET.

Eur J Nucl Med Mol Imaging. 2010 May;37(5):942-53. Epub 2009 Dec 17

Janneh O, Bray PG, Jones E, Wyen C, Chiba P, Back DJ, Khoo SH.

Concentration-dependent effects and intracellular accumulation of HIV protease inhibitors in cultured CD4 T cells and primary human lymphocytes.

J Antimicrob Chemother. 2010 May;65(5):906-16. Epub 2010 Mar 17.

Bauer M, Karch R, Neumann F, Wagner CC, Kletter K, Müller M, Loescher W, Zeitlinger M, Langer O.

Assessment of regional differences in tariquidar-induced P-glycoprotein modulation at the human blood-brain barrier.

J Cereb Blood Flow Metab. 2010 Mar;30(3):510-5. Epub 2009 Dec 16.

Ernst R, Kueppers P, Stindt J, Kuchler K, Schmitt L.

Multidrug efflux pumps: Substrate selection in ATP-binding cassette multidrug efflux pumps - first come, first served?

FEBS J. 2010 Feb 1;277(3):540-9.

Sucic S., Dallinger S., Zdrazil B, Weissensteiner R., Jorgensen T., Holy M., Kudlacek O., Seidel S., Hwan Cha J., Gether U., Newman A., Ecker G., Freissmuth M., Sitte H.

The amino terminus of monoamine transporters is a lever required for the action of amphetamines.

J Biol Chem. 2010 Apr 2;285(14):10924-38. Epub 2010 Jan 29.

Sitte HH, Freissmuth M.

The reverse operation of Na(+)/Cl(-)-coupled neurotransmitter transporters--why amphetamines take two to tango.

J Neurochem. 2010 Jan;112(2):340-55.

2009

Demel MA, Kraemer O, Ettmayer P, Haaksma EE, Ecker GF.

Predicting ligand interactions with ABC transporters in ADME.

Chem Biodivers. 2009 Nov;6(11):1960-9. Review.

Rockwell NC, Wolfger H, Kuchler K, Thorner J.

ABC transporter Pdr10 regulates the membrane microenvironment of Pdr12 in Saccharomyces cerevisiae.

J Membr Biol. 2009 May;229(1):27-52.

Egaña LA, Cuevas RA, Baust TB, Parra LA, Leak RK, Hochendoner S, Peña K, Quiroz M, Hong WC, Dorostkar MM, Janz R, Sitte HH, Torres GE.

Physical and functional interaction between the dopamine transporter and the synaptic vesicle protein synaptogyrin-3.

J Neurosci. 2009 Apr 8;29(14):4592-604.

Bernd Dörner, Claudia Kuntner, Jens P. Bankstahl, Marion Bankstahl, Johann Stanek, Thomas Wanek, Gloria Stundner, Severin Mairinger, Wolfgang Löscher, Markus Müller, Oliver Langer and Thomas Erker

Synthesis and Small-Animal Positron Emission Tomography Evaluation of [11C]-Elacridar As a Radiotracer to Assess the Distribution of P-Glycoprotein at the Blood-Brain Barrier

(doi: 10.1021/jm900940f)

Jens P. Bankstahl, Claudia Kuntner, Aiman Abrahim, Rudolf Karch, Johann Stanek, Thomas Wanek, Wolfgang Wadsak, Kurt Kletter, Markus Mueller, Wolfgang Loescher and Oliver Langer

Tariquidar-Induced P-Glycoprotein Inhibition at the Rat Blood–Brain Barrier Studied with (R)-11C-Verapamil and PET

(doi: 10.2967/jnumed.108.051235)

Martin Bauer, Rudolf Karch, Friederike Neumann, Aiman Abrahim, Claudia C. Wagner, Kurt Kletter, Markus Müller, Markus Zeitlinger, Oliver Langer

Age dependency of cerebral P-gp function measured with (R)-[11C]verapamil and PET

(doi: 10.1007/s00228-009-0709-5) Eur J Clin Pharmacol

Claudia C. Wagner, Martin Bauer, Rudolf Karch, Thomas Feurstein, Stephan Kopp, Peter Chiba, Kurt Kletter, Wolfgang Loescher, Markus Mueller, Markus Zeitlinger and Oliver Langer

A Pilot Study to Assess the Efficacy of Tariquidar to Inhibit P-glycoprotein at the Human Blood–Brain Barrier with (R)-11C-Verapamil and PET.

(doi: 10.2967/jnumed.109.063289)

Sitte HH., Freissmuth M.

GAT1 UCSD-Nature Molecule Pages (2009).

(doi:10.1038/mp.a002759.01)

Stockner T, de Vries SJ, Bonvin AM, Ecker GF, Chiba P.

Data-driven homology modelling of P-glycoprotein in the ATP-bound state indicates flexibility of the transmembrane domains.

FEBS J., 2009

Maier S, Reiterer V, Ruggiero AM, Rothstein JD, Thomas S, Dahm R, Sitte HH, Farhan H.

GTRAP3-18 serves as a negative regulator of Rab1 in protein transport and neuronal differentiation.

J Cell Mol Med., 2009

2008

Jungwirth H, Ring J, Mayer T, Schauer A, Büttner S, Eisenberg T, Carmona-Gutierrez D, Kuchler K, Madeo F.

Loss of peroxisome function triggers necrosis.

FEBS Lett., 2008

Gregori C, Schüller C, Frohner IE, Ammerer G, Kuchler K.

Weak organic acids trigger conformational changes of the yeast transcription factor War1 in vivo to elicit stress adaptation.

J Biol Chem., 2008

Ernst R, Kueppers P, Klein CM, Schwarzmueller T, Kuchler K, Schmitt L.

A mutation of the H-loop selectively affects rhodamine transport by the yeast multidrug ABC transporter Pdr5.

Proc Natl Acad Sci U S A., 2008

Reiterer V, Maier S, Sitte HH, Kriz A, Rüegg MA, Hauri HP, Freissmuth M, Farhan H.

Sec24- and ARFGAP1-dependent trafficking of GABA transporter-1 is a prerequisite for correct axonal targeting.

J Neurosci., 2008

Korkhov VM, Milan-Lobo L, Zuber B, Farhan H, Schmid JA, Freissmuth M, Sitte HH.

Peptide-based interactions with calnexin target misassembled membrane proteins into endoplasmic reticulum-derived multilamellar bodies.

J Mol Biol., 2008

Meiblitzer-Ruppitsch C, Vetterlein M, Stangl H, Maier S, Neumüller J, Freissmuth M, Pavelka M, Ellinger A.

Electron microscopic visualization of fluorescent signals in cellular compartments and organelles by means of DAB-photoconversion.

Histochem Cell Biol., 2008

Bankstahl JP, Kuntner C, Abrahim A, Karch R, Stanek J, Wanek T, Wadsak W, Kletter K, Müller M, Löscher W, Langer O.

Tariquidar-induced P-glycoprotein inhibition at the rat blood-brain barrier studied with (R)-11C-verapamil and PET.

J Nucl Med., 2008